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KMID : 0380020110260030183
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Korean Journal of Biotechnology and Bioengineering
2011 Volume.26 No. 3 p.183 ~ p.188
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Mal-differentiation of Stem Cells: Cancer and Ageing
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Lee Mi-Ok
Cha Hyuk-Jin
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Abstract
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Adult stem cells, which have characteristic of self-renewal and multipotency, are specialized cell types, responsible for the tissue regeneration of the damaged tissue. Recent studies suggest that stem cells senescence (or stem cells' ageing) is closely associated with the variety of ageing-related phenotypes such as tissue atrophy, degenerative diseases and onset of cancers. During ageing, declining of stem cells function and subsequently occurring mal-differentiation of stem cells would be important to understand the biological process of development of ageing-related phenotypes such as tissue degenerations and cancers. This review focuses on the DNA damage stress as a cause of senescence of stem cells and their mal differentiation, which is closely link to defect of regeneration potentials and neoplastic transformation. Understanding of molecular mechanisms governingsuch events is likely to have important implications for developing novel avenues for balancing tissue homeostasis longer period of time, further leading to 'Healthy ageing'.
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KEYWORD
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Maldifferentiation, adult stem cell, ageing, DNA damage, cancer, tumor suppressor, healthy ageing
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